References to any names, marks, products, or services of third parties or. The submandibular gland is the second largest salivary gland, weighing approximately 7 to 8 g. Myoepitheliomas are most common in young adults between the ages of 30 and 50 and there are very. Lymphoepitheliallike carcinoma of the parotid gland. Salivary gland tumors are a morphologically and clinically diverse group of neoplasms, which may present significant diagnostic and management challenges. The acini are surrounded by contractile myoepithelial cells. Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or basket cells which are found between the basement membrane and the.
Nov 18, 2016 myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Dec 12, 2011 myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and neck that is usually benign. Histopathological examination is the most important method of diagnosis, predicting prognosis by typing, staging and grading in case of malignant neoplasms of salivary gland. Salivary gland neoplasms comprise less than 3% of all neoplasms in the head and neck region. Benign neoplasms of salivary glands i webpathology. Hemangioma is a common soft tissue lesion in the head and neck region. Minor salivary gland tumors are a subtype of salivary gland tumors originating from the minor salivary glands, which are found in the lips, tongue, hard palate, and the mucosa of the oropharynx and larynx, among other locations epidemiology. Mucoepidermoid carcinoma incidence is about 16% of minor salivary gland tumours, second to adenoid cystic carcinoma. The treatment of parotid gland conditions is complex and extremely delicate. Case epithelialmyoepithelial carcinoma of the report base. We report the case of a 72yearold malay female after presentation with sore throat, fever and odynophagia, was diagnosed with mucoepidermoid carcinoma of the soft palate.
Salivary gland neoplasm an overview sciencedirect topics. An exception is represented by the eskimo population, in which 60% of the parotid gland tumors are malignant, the majority being lymphoepitheliallike carcinoma lelc. Review of the major and minor salivary glands, part 1. Salivary gland swelling patient questionnaire iowa head and. Minor salivary gland tumors msgts are infrequent, accounting for 1015% of all salivary neoplasms, and are fundamentally located in the palate 50%, lips 15%. To conclude, epithelialmyoepithelial carcinoma is a rare salivary gland tumor with clinicopathologic diversity but. While complaints of xerostomia may be indic ative of a salivary gland disorder, salivary diseases can present without symptoms. Salivary gland tumors include a wide range of tumor types, which can be either benign or malignant. The major salivary glands consist of the parotid, submandibular, and sublingual glands. Patients usually present with a welldefined painless swelling in front of or behind the ear parotid tumors. These cases are from the files of the institute of pathology at, the tniversity of tennessee and cover tlie period from 1942 to 1950. Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland.
The most common spindle cell lesions of the salivary gland are myoepithelialpredominant pleomorphic adenoma, myoepithelioma, and schwannoma, which will be the focus of this chapter. These tumors are rare, with an overall incidence in the western world of approximately 2. Myoepithelioma of the head and neck, also myoepithelioma, is a salivary gland tumour of the head and neck that is usually benign as the name suggests, it consists of myoepithelial cells. It is a benign salivary gland tumor that consists entirely of myoepithelial cells with variable cellular morphologies including spindle, epithelioid, plasmacytoid, or clear cells. Mar 27, 2018 myoepithelioma of salivary gland is an uncommon benign tumor typically arising in the major salivary glands. Myoepitheliomas are most common in young adults between the ages of 30 and 50 and there are very few cases reported in. It accounts for 60% to 73% of the parotid gland tumors, 12% to 60% of the submandibular and 14% to 70% of the minor salivary glands tumors 24. Myoepithelioma is a rare benign tumor of the salivary glands and is usually seen in the parotid gland and the minor salivary glands. Most 70% salivary gland tumors originate in the parotid gland, with the bulk of the remainder arising in the submandibular gland 8% and in the minor salivary glands 22%.
An external file that holds a picture, illustration, etc. Pleomorphic adenoma a salivary gland tumor as nasal mass. Any information contained in this pdf file is automatically generated from digital material submitted to epos by third parties in the form of scientific presentations. Salivary gland tumors represent 3% of all head and neck tumors. However it can present in the minor salivary glands, especially in the soft palate. Objective to analyze the importance of unique cytoarchitectural patterns and the immunohistochemical profile in the diagnosis of myoepithelial carcinomas. Lung carcinomas of the salivary gland type are also known as salivary gland type tumors of the lung sgttls or bronchial gland neoplasms the usual consignation to the group of nonsmall cell lung cancer nsclc may be unfortunate because the clinical behavior of sgttls can be quite different from that of conventional lung cancers 5 epidemiology. Normal salivary gland myoepithelial cells stain negative for vimentin, 10 while neoplastic myoepithelial cells stain positive for it. Minor salivary gland tumors are a subtype of salivary gland tumors originating from the minor salivary glands, which are found in the lips, tongue, hard palate, and the mucosa of the oropharynx and larynx, among other locations. Such lesion shows a varied pattern of morphological growth, it may be solid, myxoid or reticular.
Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or basket cells which are found between the basement membrane and the basal. Hokkaido university collection of scholarly and academic papers. Sep 10, 2018 epithelialmyoepithelial carcinoma emc of salivary gland is a malignant epithelial tumor, composed of two distinct cell types, affecting either the major or minor salivary glands. Histopathological findings of pleomorphic adenomas of the. The parotid salivary gland being one of the major salivary glands of.
Myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Original article histopathological study of salivary gland. Modern sialography for screening of salivary gland. Myoepithelioma of salivary gland is an uncommon benign tumor typically arising in the major salivary glands. We herein report an extremely rare case of this tumor with lipomatous. Msgts account for 15% of all salivary gland tumors.
It can be present in individuals of a wide age range including children and adults the cause of formation of salivary gland myoepithelioma is not wellunderstood, although certain chromosomal alterations and gene mutations have been. Tumors of minor salivary glands e583 introduction salivary gland neoplasms represent less than 1% of all tumors, and 35% of all head and neck neoplasms. It can be said that mec has the capacity to differentiate into epithelial as well as the mesenchymal components in a tumour and these tumour cells have been termed the nmec. Aug 24, 2009 salivary gland neoplasms slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. It differs from the pleomorphic adenoma because it does not bear any ductal component5. The major and minor salivary glands of the head and neck are important structures that contribute to many of the normal physiologic processes of the aerodigestive tract. It was once considered to be a type of pleomorphic adenoma pa, but myoepitheliomas are today believed to be relatively aggressive tumors. It is observed in a wide age category of children and adults. Adenoid cystic carcinoma is the second most common malignant salivary gland tumor. Although myoepitheliomas have been reported in all major and most locations containing the minor salivary glands, 18, 19 the parotid gland is the primary site of occurrence of most reported tumors 4050%, 8, 11 followed by the minor salivary glands as the second most preferred site of which the palate is the most common location 21%. Myoepithelioma, salivary glands, mouse springerlink. Salivary gland swelling questionnaire click to download pdf.
The annual incidence of salivary gland cancers ranges from 0. Parotid gland the parotid gland is composed mainly of serous cells and produces saliva that is watery and rich in enzymes amylase and lysozyme and antibodies. As the name suggests, it consists of myoepithelial cells. Developmental changes in the parotid salivary gland of. Mucoepidermoid carcinoma of the soft palate salivary gland. Rare benign tumor composed only of myoepithelial cells. Aug 17, 2006 hemangioma is a common soft tissue lesion in the head and neck region. Myoepithelial cells mec of the salivary glands in health. In addition to the variety of lesions, salivary gland tumors with a predominant spindle cell pattern are rare, accounting for less than 3% of salivary gland aspirates. Mucoepidermoid tumour, salivary gland neoplasms, minor salivary gland introduction. Mar 18, 2015 myoepithelioma was recognized as a histologically distinct entity by the world health organization who in 1991. Classically, they are found in the parotid gland or palate.
The basic structure of a salivary gland tissue is a branching tubule or duct that has the princi pal secretory cells, the acinar cells, at the ends of the branches and. Diagnosing, managing, and preventing salivary gland disorders. The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the oral cavity. Diagnosis of salivary disorders begins with a careful medical history, head, and neck exam ination. Case epithelialmyoepithelial carcinoma of the report base of. Myoepithelioma me is a benign salivary gland tumor composed almost exclusively of sheets, islands, or cords of cells with myoepitheliomal differentiation. We report a rare histological finding of salivary gland structures within a cavernous hemangioma, which may or may.
Mar 07, 2016 the submandibular gland is the second largest salivary gland, weighing approximately 7 to 8 g. Major salivary glands sg such as the submandibular and parotid glands are. Parotid gland is the most commonly affected among major salivary glands. Salivary gland tumors tehran university of medical sciences. The role of mec in salivary gland tumours is well established. The most common site of minor salivary gland tumors of the head and neck is the oral cavity. Myoepithelioma is a relatively rare form of salivary gland tumor, accounting for less than 1% of all salivary gland neoplasms. About 60% to 70% of mca develop in a benign mixed tumor. The overall incidence of salivary gland tumors varies around the world from approximately 0.
Salivary gland and nasopharyngeal cancers in individuals with acquired immunodeficiency syndrome in united states. Myoepithelioma of salivary glands are very rare, accounting for only 1%1. These segments have a bilayered cellular compo sition of luminal cells and abluminal. An approach to the why is salivary gland pathology. When its helpful tumor stain result mucoepidermoid carcinoma mucicarmine intracytoplasmic mucin oncocytomacarcinoma ptah mitochondria acinic cell carcinoma pasd zymogen cytoplasmic granules. The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the. Discussion salivary gland tumors are complex neoplasms which account for 3% of all head and neck tumours. Myoepithelioma of minor salivary glands a diagnostic. Lung carcinomas of the salivary gland type radiology. Epithelialmyoepithelial carcinoma of salivary gland. Among these 8590% originates from the major salivary glands.
Since 1943 when sheldon identified them and characterized them as myoepithelioma, less than 100 cases have been reported in the literature. Pleomorphic adenoma is the most common benign salivary gland tumor. Eighty percent occur in the parotid gland, of which approximately 80% are benign and 20% are malignant. Instructions to patients submandibular salivary stones. They occur over a wide age range but the peak incidence is in 6th to 7th decades with a slight female predominance. Physiology, pathology and regeneration of salivary glands mdpi. Epithelialmyoepithelial carcinoma of the parotid gland. It is most commonly found in the major salivary glands parotid but may also present in the minor salivary glands. Mumps virus, salivary gland calculi, salivary glands, sialadenitis, sjogrens syndrome. They most commonly affect the major and minor salivary glands with the parotid gland being the most common, approximately 40%. Salivary gland tumours or neoplasms are tumours that form in the tissues of salivary glands. Although parotid gland constitutes 60% of all pleomorphic adenomas, minor salivary glands constitute only 8% of them 1. The majority of these neoplasms are benign and only 20% are malignant.
We report a rare histological finding of salivary gland structures within a cavernous hemangioma, which may or may not have. The abundant serous exocrine cells make up the bulk of the gland. The tumor is composed exclusively of myoepithelial cells that show spindle, plasmacytoid, and clear cell morphology. The sublingual gland sl secretes mucous, a viscous solution rich in mucins 35. Salivary gland myoepithelial cell pleomorphic adenoma salivary gland tumor minor salivary gland these keywords were added by machine and not by the authors.
Pa is a slowgrowing benign salivary gland tumor, most commonly arising in the parotid gland. This process is experimental and the keywords may be updated as the learning algorithm improves. A similar tumor type may be found in the tongue, referred to as ectomesenchymal chondromyxoid tumor. Strategies for developing functional secretory epithelia from. Plasmacytoid myoepithelioma of minor salivary glands. Worldwide annual incidence of salivary gland tumours varies from 0. Despite accumulated knowledge on parotid glands, the debate whether soft food affects submandibular and sublingual glands. Lung carcinomas of the salivary gland type are also known as salivary glandtype tumors of the lung sgttls or bronchial gland neoplasms the usual consignation to the group of nonsmall cell lung cancer nsclc may be unfortunate because the clinical behavior of sgttls can be quite different from that of conventional lung cancers 5. Although surgery has been used for treatment of epithelialmyoepithelial carcinoma at all sites, the present case shows that chemotherapy and radiotherapy may be a viable option for treating epithelialmyoepithelial carcinoma of the base of tongue. In addition to being intimately involved with the bodys critical nerves and structures, the parotid glands are also responsible for a host of important functions, including protecting the teeth from decay, initiating digestion and moisturizing the mouth. Salivary gland tumours are rare and most cases are referred to the head and neck clinic.
Epithelialmyoepithelial carcinoma emc of salivary gland is a malignant epithelial tumor, composed of two distinct cell types, affecting either the major or minor salivary glands. Female patients are more affected than males 2,5,8,9 and the peak incidence occurs in. If you continue browsing the site, you agree to the use of cookies on this website. Discussion pa is a slowgrowing benign salivary gland tumor, most commonly arising in the parotid gland. Research efforts have been made to develop human salivary gland sg secretory epithelia for. Although almost 40 histologic types of epithelial tumors of the salivary glands exist, some are exceedingly rare and may be the subject of only a few case reports. Patients a total of 51 patients with myoepithelialrich.
Sublingual gland is poorly encapsulated, smallest major salivary gland, weighing approximately 2 to 3 gm. Insfihtte of pathology, unirrxilil nf tfnncsm r, the minor salivary glands, or socalled accessory. Mucoepidermoid carcinoma of the salivary gland is one of the differential diagnoses. The most common site is parotid gland with a few arising in minor salivary glands of the oral cavity and palate. Sialendoscopy in obstructive diseases of the major salivary glands. Salivary gland neoplasms general features site frequency proportion malignant parotid 65% 25% submandibular 10% 40% sublingual myoepithelioma myoepithelioma, parotid gland. Minor salivary gland tumors radiology reference article. The risk factors include radiation exposure, familial predisposition.
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